CCL14
CCL14, also known as Chemokine (C-C motif) ligand 14, is a small cytokine belonging to the CC chemokine family that is also known as HCC-1 (hemofiltrate CC chemokine 1). It is produced as a protein precursor that is cleaved to generate the mature protein. CCL14 is expressed in various tissues, including the liver and the kidney, and may be involved in the recruitment of monocytes, lymphocytes and neutrophils.
Structure[edit | edit source]
CCL14 is a small protein of 74 amino acids. It is produced as a precursor protein that is cleaved to generate the mature protein. The mature protein is a monomer that is secreted into the extracellular space.
Function[edit | edit source]
CCL14 is a chemotactic factor that attracts monocytes, lymphocytes and neutrophils. It may also be involved in the formation of blood vessels. It is also thought to play a role in the immune response to infection and inflammation.
Clinical significance[edit | edit source]
CCL14 may be involved in the pathogenesis of various diseases, including cancer, autoimmune diseases, and inflammatory diseases. It may also play a role in the immune response to infection.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
