IL36A

IL36A‏‎ is a protein that in humans is encoded by the IL36A gene. It is a member of the interleukin family, specifically the IL-1 family, and is involved in various immune responses and inflammatory processes.

Function[edit | edit source]

IL36A, also known as Interleukin-36 alpha, is a pro-inflammatory cytokine which plays a crucial role in the immune system. It is primarily expressed in keratinocytes, the predominant cell type in the epidermis, and is involved in the activation of immune cells such as T cells and dendritic cells. This activation leads to the production of other pro-inflammatory cytokines, amplifying the immune response.

Clinical significance[edit | edit source]

Alterations in the function or expression of IL36A have been associated with several diseases. For example, mutations in the IL36A gene have been linked to generalized psoriasis, a chronic skin disease characterized by red, scaly patches. In addition, elevated levels of IL36A have been observed in patients with rheumatoid arthritis, suggesting a potential role in the pathogenesis of this disease.

Research[edit | edit source]

Research into IL36A is ongoing, with studies investigating its role in various diseases and potential as a therapeutic target. For example, drugs that inhibit the activity of IL36A may be beneficial in the treatment of inflammatory diseases such as psoriasis and rheumatoid arthritis.