CSF2RB
CSF2RB (Colony Stimulating Factor 2 Receptor Beta Common Subunit) is a protein that in humans is encoded by the CSF2RB gene. This protein is a critical component of the cytokine receptor system, which is involved in the regulation of immune response and hematopoiesis.
Function[edit | edit source]
The CSF2RB protein is a high-affinity receptor that binds to granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 3 (IL3), and interleukin 5 (IL5). It plays a vital role in the function of the immune system and the production of blood cells. The protein is located on the surface of cells and is involved in signaling pathways that regulate cell growth and differentiation.
Clinical significance[edit | edit source]
Mutations in the CSF2RB gene can lead to diseases such as Pulmonary Alveolar Proteinosis (PAP), a rare lung disease, and Surfactant Metabolism Dysfunction (SMD), a group of lung disorders. Research is ongoing to understand the role of CSF2RB in these and other diseases.
See also[edit | edit source]
- Colony-stimulating factor
- Cytokine receptor
- Granulocyte-macrophage colony-stimulating factor
- Interleukin 3
- Interleukin 5
References[edit | edit source]
External links[edit | edit source]
- CSF2RB at the National Center for Biotechnology Information (NCBI)
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