IFNA21

IFNA21 is a gene that in humans encodes the alpha 21 subunit of interferon. Interferons are proteins released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites or tumor cells. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors.

Function

The protein encoded by this gene is a member of the interferon regulatory factor (IRF) family, which is characterized by a conserved N-terminal DNA-binding domain and a less conserved C-terminal transactivation domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes.

Clinical significance

Interferons have been recognized for their role in fighting infections and in immune system regulation. They are used therapeutically in the treatment of infections such as hepatitis B and C, and certain cancers.

See also

• Interferon
• Interferon alpha
• Interferon regulatory factor

External links

• NCBI Gene
• UniProt

IFNA21 Resources
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