CCL18

CCL18 is a small cytokine known as a chemokine that is also known as Pulmonary and Activation-Regulated Chemokine (PARC). It is expressed in the lung, lymph nodes, and peripheral blood leukocytes. CCL18 attracts immune cells, such as lymphocytes, monocytes, and dendritic cells, to sites of inflammation in the body.

Function

CCL18 is a member of the CC chemokine family, and is predominantly expressed in the lung, lymph nodes, and peripheral blood leukocytes. It has chemotactic activity for lymphocytes, monocytes, and dendritic cells. This chemokine is believed to play a role in pulmonary inflammation and fibrosis.

Clinical significance

CCL18 has been associated with various diseases, including pulmonary fibrosis, asthma, and cancer. It is often found at elevated levels in the blood plasma of patients with these conditions. In cancer, CCL18 has been shown to promote tumor growth and metastasis.

See also

• Chemokine
• Cytokine
• Pulmonary fibrosis
• Asthma
• Cancer

References

CCL18 Resources
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