Leukemia inhibitory factor
Leukemia inhibitory factor (LIF) is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate.
Function[edit | edit source]
LIF is normally expressed in the trophoblast of the uterus and helps prevent the immune system from attacking the developing embryo. Following implantation, LIF also affects bone metabolism, neural development and inflammation.
Clinical significance[edit | edit source]
LIF has the capacity to induce terminal differentiation in leukemic cells and other malignant cells, and may have potential use in cancer therapy.
Interactions[edit | edit source]
Leukemia inhibitory factor has been shown to interact with LIFR and IL6ST.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- LIF at the US National Library of Medicine Medical Subject Headings (MeSH)
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Contributors: Prab R. Tumpati, MD
