IL36B
IL36B is a protein that in humans is encoded by the IL36B gene. It is a member of the interleukin family, specifically the IL-1 family, and is involved in various immune responses and inflammatory processes.
Function[edit | edit source]
IL36B, also known as Interleukin-36 beta, is a pro-inflammatory cytokine which plays a crucial role in the immune system. It is primarily expressed in keratinocytes, the predominant cell type in the epidermis, and is involved in the activation of NF-kappaB and MAP kinases. This leads to the production of pro-inflammatory cytokines and chemokines, which contribute to the inflammatory response.
Clinical significance[edit | edit source]
Alterations in the function or expression of IL36B have been associated with several diseases. For example, mutations in the IL36B gene have been linked to generalized psoriasis, a chronic skin disease characterized by red, scaly patches. In addition, elevated levels of IL36B have been observed in the skin lesions of patients with psoriatic arthritis, suggesting a potential role in the pathogenesis of this condition.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- IL36B at GeneCards
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Contributors: Prab R. Tumpati, MD
