OX40L

OX40L or CD252 is a protein that in humans is encoded by the TNFSF4 gene. It is a member of the tumor necrosis factor (TNF) ligand family and is a ligand for the receptor OX40.

Function

OX40L is a type-II membrane protein primarily expressed on antigen-presenting cells such as dendritic cells, B cells, and macrophages. It provides co-stimulatory signals necessary for T cell activation and survival. OX40L binds to OX40 receptors on T cells, leading to the proliferation of T cells and the production of cytokines.

Clinical Significance

OX40L has been implicated in several autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, and atherosclerosis. It is also involved in allergy and asthma pathogenesis.

Therapeutic Potential

Due to its role in T cell activation, OX40L is being explored as a potential target for immunotherapy in cancer and autoimmune diseases. Blocking the interaction between OX40L and OX40 can potentially reduce inflammation and autoimmunity, while enhancing this interaction could boost anti-tumor immunity.

See Also

• Tumor necrosis factor
• OX40
• Immunotherapy
• Autoimmune diseases