CCL13
CCL13 (Chemokine (C-C motif) ligand 13) is a small cytokine belonging to the CC chemokine family that is also known as Monocyte Chemoattractant Protein 4 (MCP-4). It is predominantly expressed in monocytes, lymphocytes, basophils, and eosinophils. CCL13 is known to play roles in immunoregulatory and inflammatory processes.
Function[edit | edit source]
CCL13 is involved in the recruitment of leukocytes to the site of inflammation. It is also known to induce the migration of monocytes, lymphocytes, basophils, and eosinophils towards the site of inflammation. The chemotactic activity of CCL13 is mediated by CCR2, CCR3, and CCR5.
Clinical significance[edit | edit source]
CCL13 has been implicated in various inflammatory diseases such as rheumatoid arthritis, asthma, and atopic dermatitis. It has also been associated with the progression of HIV.
See also[edit | edit source]
- Chemokine
- Cytokine
- Monocyte
- Lymphocyte
- Basophil
- Eosinophil
- Leukocyte
- CCR2
- CCR3
- CCR5
- Rheumatoid arthritis
- Asthma
- Atopic dermatitis
- HIV
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Contributors: Prab R. Tumpati, MD
