Oncostatin M

Oncostatin M (OSM) is a protein that in humans is encoded by the OSM gene. It is a member of the interleukin 6 (IL-6) group of cytokines which are involved in the regulation of cell growth and differentiation.

Function

Oncostatin M is a growth regulator which inhibits the proliferation of a number of tumor cell lines. It stimulates controlled growth of cancer cells and promotes differentiation of a variety of cell types, including leukemia cells, fibroblasts and neuronal cells.

Structure

The OSM gene is located on the long arm of chromosome 22 (22q12.2). The protein encoded by this gene is a secreted glycoprotein that is approximately 28 kDa in size. It is composed of 227 amino acids and has a four-helix bundle structure, similar to other members of the IL-6 family.

Clinical significance

Oncostatin M has been implicated in a number of physiological processes, including inflammation, hematopoiesis, and bone remodeling. It has also been associated with several pathological conditions, such as rheumatoid arthritis, asthma, and certain types of cancer.

Research

Research into Oncostatin M has focused on its potential therapeutic applications, particularly in the treatment of cancer. Studies have shown that OSM can inhibit the growth of certain types of cancer cells, suggesting that it may have potential as a novel anticancer therapy.

See also

• Cytokine
• Interleukin 6
• Cell growth
• Cell differentiation
• Cancer