CCL25

CCL25 is a small cytokine belonging to the CC chemokine family that is also known as TECK (thymus-expressed chemokine). This chemokine is expressed in thymus and small intestine, and the gene is located on chromosome 19 in humans. It elicits its effects on its target cells by interacting with the chemokine receptor CCR9. CCL25 is chemotactic for dendritic cells, lymphocytes, and eosinophils.

Structure

CCL25 is a small protein of 119 amino acids. It is a member of the CC chemokine family, which is characterized by two adjacent cysteines near the N terminus. The gene for CCL25 is located on chromosome 19 in humans.

Function

CCL25 is expressed in the thymus and the small intestine. It is involved in the homing of T cells and dendritic cells to the gut. The interaction of CCL25 with its receptor, CCR9, is important for the T cell development and function.

Clinical significance

CCL25 and its receptor CCR9 have been implicated in the pathogenesis of several diseases, including inflammatory bowel disease, celiac disease, and colorectal cancer. In these diseases, the CCL25-CCR9 axis is thought to mediate the migration of inflammatory cells to the gut, contributing to inflammation and tissue damage.

See also

• Chemokine
• Cytokine
• CCR9
• Inflammatory bowel disease
• Celiac disease
• Colorectal cancer

References

CCL25 Resources
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