CCR9
CCR9 is a gene that encodes the C-C chemokine receptor type 9 protein in humans. It is a member of the G protein-coupled receptor family and plays a crucial role in the immune system.
Function[edit | edit source]
The CCR9 gene is involved in the mediation of chemotaxis. This process is essential for the movement of cells in response to a chemical stimulus. The protein encoded by the CCR9 gene is specifically responsive to the chemokine known as CCL25. It is believed to be important for the homing of T cells to the small intestine.
Clinical significance[edit | edit source]
Alterations in the normal function of the CCR9 gene have been associated with numerous health conditions. For instance, it has been linked to celiac disease, a condition characterized by an adverse reaction to gluten. Additionally, it has been implicated in various types of cancer, including breast cancer and melanoma.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- CCR9 at the US National Library of Medicine Medical Subject Headings (MeSH)
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Contributors: Prab R. Tumpati, MD
