CCR9

CCR9 is a gene that encodes the C-C chemokine receptor type 9 protein in humans. It is a member of the G protein-coupled receptor family and plays a crucial role in the immune system.

Function

The CCR9 gene is involved in the mediation of chemotaxis. This process is essential for the movement of cells in response to a chemical stimulus. The protein encoded by the CCR9 gene is specifically responsive to the chemokine known as CCL25. It is believed to be important for the homing of T cells to the small intestine.

Clinical significance

Alterations in the normal function of the CCR9 gene have been associated with numerous health conditions. For instance, it has been linked to celiac disease, a condition characterized by an adverse reaction to gluten. Additionally, it has been implicated in various types of cancer, including breast cancer and melanoma.

See also

• Chemokine receptor
• Chemotaxis
• CCL25
• G protein-coupled receptor

External links

• CCR9 at the US National Library of Medicine Medical Subject Headings (MeSH)