IL1F9

IL1F9 is a member of the interleukin-1 cytokine family. This cytokine is a secreted protein that has been identified as a ligand of the recently discovered interleukin 1 receptor, IL1RL2. This receptor has been shown to be expressed in skin and activated by interleukin 1 family members. Studies of the mouse counterpart suggest that this cytokine can induce NF-kappaB activation, and its expression is under the regulation of NF-kappaB. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Function

IL1F9 is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 1 receptor-like 2 (IL1RL2). Interleukin 4 release by human basophils can also be induced by this cytokine.

Clinical Significance

IL1F9 has been associated with diseases such as psoriasis and rheumatoid arthritis. It is thought to play a role in the inflammation process involved in these diseases.

See Also

• Interleukin-1 family
• Interleukin 1 receptor
• NF-kappaB
• Psoriasis
• Rheumatoid arthritis