IL36G

IL36G‏‎ is a gene that encodes the protein IL-36 gamma, a member of the Interleukin family of cytokines. These proteins are involved in the immune response and inflammation processes in the body. IL36G‏‎ is particularly associated with skin diseases, such as psoriasis and eczema, and other inflammatory conditions.

Function[edit | edit source]

The IL36G‏‎ gene encodes the IL-36 gamma protein, which is a part of the IL-36 subfamily within the larger Interleukin-1 cytokine family. This protein is primarily expressed in the skin, particularly in keratinocytes, and plays a crucial role in the immune response and inflammation. It is involved in the activation of NF-kappaB and MAPK signaling pathways, which are essential for the production of pro-inflammatory cytokines.

Clinical Significance[edit | edit source]

Mutations in the IL36G‏‎ gene have been associated with the development of several inflammatory skin diseases. These include generalized pustular psoriasis (GPP), a severe form of psoriasis, and eczema, a condition characterized by itchy, red, and inflamed skin. Studies have also suggested a role for IL36G‏‎ in other inflammatory conditions, such as rheumatoid arthritis and inflammatory bowel disease.

Research[edit | edit source]

Research into the IL36G‏‎ gene and its encoded protein is ongoing, with a focus on understanding its role in inflammation and the immune response. This research could potentially lead to new treatments for inflammatory skin diseases and other conditions associated with IL36G‏‎.