IL36G
IL36G is a gene that encodes the protein IL-36 gamma, a member of the Interleukin family of cytokines. These proteins are involved in the immune response and inflammation processes in the body. IL36G is particularly associated with skin diseases, such as psoriasis and eczema, and other inflammatory conditions.
Function[edit | edit source]
The IL36G gene encodes the IL-36 gamma protein, which is a part of the IL-36 subfamily within the larger Interleukin-1 cytokine family. This protein is primarily expressed in the skin, particularly in keratinocytes, and plays a crucial role in the immune response and inflammation. It is involved in the activation of NF-kappaB and MAPK signaling pathways, which are essential for the production of pro-inflammatory cytokines.
Clinical Significance[edit | edit source]
Mutations in the IL36G gene have been associated with the development of several inflammatory skin diseases. These include generalized pustular psoriasis (GPP), a severe form of psoriasis, and eczema, a condition characterized by itchy, red, and inflamed skin. Studies have also suggested a role for IL36G in other inflammatory conditions, such as rheumatoid arthritis and inflammatory bowel disease.
Research[edit | edit source]
Research into the IL36G gene and its encoded protein is ongoing, with a focus on understanding its role in inflammation and the immune response. This research could potentially lead to new treatments for inflammatory skin diseases and other conditions associated with IL36G.
See Also[edit | edit source]
- Interleukin
- Interleukin-1
- NF-kappaB
- Psoriasis
- Eczema
- Rheumatoid arthritis
- Inflammatory bowel disease
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Contributors: Prab R. Tumpati, MD