Monokine

Monokine is a type of cytokine, a broad category of small proteins that are important in cell signaling. They are produced by a broad range of cells, including immune cells like macrophages, B cells, T cells and Mast cells, as well as endothelial cells, fibroblasts, and various stromal cells.

Monokines are named for their production by mononuclear phagocytic cells, such as monocytes and macrophages. They are involved in a wide range of physiological processes, including the regulation of the immune and inflammatory responses, as well as the development of hematopoietic cells.

Function

Monokines play a crucial role in the body's response to disease and injury. They are involved in the regulation of the immune response, including the activation and differentiation of T cells and B cells, the recruitment of neutrophils to sites of infection, and the activation of natural killer cells.

In addition to their role in the immune response, monokines also play a role in the regulation of inflammation. They can induce the production of prostaglandins and other inflammatory mediators, and can also regulate the expression of adhesion molecules on the surface of endothelial cells, which allows for the recruitment of immune cells to sites of inflammation.

Clinical significance

Due to their role in the immune response and inflammation, monokines have been implicated in a number of diseases, including autoimmune diseases, inflammatory diseases, and cancers. They are also involved in the pathogenesis of sepsis, a severe systemic inflammatory response to infection.

In addition to their role in disease, monokines also have potential therapeutic applications. For example, they can be used to boost the immune response in patients with immunodeficiencies, or to suppress the immune response in patients with autoimmune diseases.

See also

• Cytokine
• Interleukin
• Chemokine
• Lymphokine

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