Type II cytokine receptor

Type II cytokine receptor is a type of cytokine receptor that specifically binds and responds to type II cytokines. These receptors are integral membrane proteins that are involved in various immune responses and other physiological processes in the body.

Structure

Type II cytokine receptors are characterized by their structure, which typically consists of multiple subunits. The extracellular domain of these receptors is responsible for binding to the cytokine, while the intracellular domain is involved in signal transduction. The structure of these receptors is crucial for their function, as it allows them to specifically recognize and bind to their corresponding cytokines.

Function

The primary function of type II cytokine receptors is to mediate the effects of type II cytokines. These cytokines, which include interferons and interleukins, play a crucial role in immune responses. When a type II cytokine binds to its receptor, it triggers a cascade of intracellular events that ultimately lead to the activation of immune cells and the production of other immune mediators.

Clinical significance

Abnormalities in type II cytokine receptors can lead to various health problems. For example, mutations in these receptors can result in immune deficiencies, while overactivity can contribute to autoimmune diseases. Furthermore, some types of cancer cells can exploit these receptors to evade the immune system.

See also

• Cytokine
• Cytokine receptor
• Type I cytokine receptor
• Interferon
• Interleukin

References

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