Interleukins

Interleukins are a group of cytokines that are produced and released by leukocytes. They are a part of the body's immune system and play a crucial role in the body's response to disease and infection.

Overview

Interleukins were first identified in the 1970s and have since been found to be produced by a variety of cell types, including macrophages, B cells, T cells, and endothelial cells. They are primarily involved in cell-to-cell communication and can stimulate the growth and differentiation of other cell types, including immune cells and hematopoietic cells.

Function

Interleukins have a wide range of functions in the body. They can act as growth factors, stimulating the growth and differentiation of specific cell types. They can also act as inflammatory mediators, promoting inflammation in response to injury or infection. Additionally, they can act as immunomodulators, modulating the body's immune response to disease and infection.

Types of Interleukins

There are currently over 30 known types of interleukins, each with its own specific function. Some of the most well-known include:

• Interleukin-1 (IL-1): This interleukin is primarily involved in the inflammatory response and can stimulate the production of other cytokines.
• Interleukin-2 (IL-2): This interleukin is primarily involved in the growth and differentiation of T cells.
• Interleukin-6 (IL-6): This interleukin is involved in the immune response and can stimulate the production of antibodies.
• Interleukin-10 (IL-10): This interleukin is an anti-inflammatory cytokine that can inhibit the production of other cytokines.

Clinical Significance

Interleukins have been found to play a role in a variety of diseases, including autoimmune diseases, cancer, and infectious diseases. They are also being investigated for their potential use in the treatment of these diseases.

See Also

• Cytokines
• Immune System
• Inflammation

Interleukins Resources
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