CCL23
CCL23 (Chemokine (C-C motif) ligand 23), also known as MPIF-1 (Myeloid Progenitor Inhibitory Factor 1), is a small cytokine belonging to the CC chemokine family that is also known as CK-beta-8. This chemokine is secreted by activated monocytes and macrophages and is chemotactic for resting T cells and monocytes.
Function[edit | edit source]
CCL23 is involved in immune responses and inflammation. It is secreted by activated monocytes and macrophages and is chemotactic for resting T cells and monocytes. The gene for CCL23 is located on human chromosome 17 within a large cluster of other chemokines.
Clinical significance[edit | edit source]
CCL23 has been implicated in several diseases, including rheumatoid arthritis, asthma, and atherosclerosis. It is also involved in the recruitment of monocytes into the arterial wall, which is a key event in the pathogenesis of atherosclerosis.
Interactions[edit | edit source]
CCL23 has been shown to interact with chemokine receptors such as CCR1 and CCR3. These interactions play a crucial role in the chemotactic properties of CCL23.
See also[edit | edit source]
- Chemokine
- Cytokine
- Monocyte
- Macrophage
- T cell
- Chemokine receptor
- Rheumatoid arthritis
- Asthma
- Atherosclerosis
References[edit | edit source]
CCL23 Resources | ||
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