Interleukin 22
Interleukin 22 (IL-22) is a protein that in humans is encoded by the IL22 gene. It is a member of a group of molecules known as cytokines, which are important in the immune response. IL-22 is produced by several types of cells, including T cells and natural killer cells, and has various effects on the cells that it targets.
Function[edit | edit source]
IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-24, IL-26, IL-28, and IL-29. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits antigen presentation by dendritic cells. Two types of IL-22 binding receptor have been discovered, both of which are members of the class II cytokine receptor (CRF2) family: IL-22Ra1 and IL-22Ra2.
Clinical significance[edit | edit source]
IL-22 has been shown to be involved in several types of autoimmune disease, including psoriasis, rheumatoid arthritis, and inflammatory bowel disease. It is also implicated in the immune response to tuberculosis. IL-22 may be a potential therapeutic target in these diseases.
References[edit | edit source]
External links[edit | edit source]
- IL22 gene at NCBI
- IL22 protein at UniProt
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