Interleukin 7

Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 is a cytokine that is important for B cell and T cell development.

Function

IL-7 is a glycoprotein which promotes the proliferation of precursor B cells, T cells, and NK cells. It plays a key role in V(D)J recombination of the T cell receptor. In addition, it may have a role in increasing the tumorigenicity of leukemia cells.

Clinical significance

IL-7 can induce the proliferation of lymphocytes. It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis. It enhances the function of dendritic cells. It is also essential for the maintenance of T cell homeostasis.

Interactions

Interleukin 7 has been shown to interact with IL7R.

See also

• Interleukin
• Interleukin receptor
• Cytokine
• B cell
• T cell
• NK cell
• V(D)J recombination
• Leukemia
• Lymphocyte
• Dendritic cell
• T cell homeostasis

External links

• IL7 gene at NCBI
• IL7 protein at UniProt

Interleukin 7 Resources
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