CD153

CD153 also known as CD30L or CD30 ligand is a cell surface protein that belongs to the TNF (tumor necrosis factor) superfamily. It is expressed on activated T cells and regulates B cell function by binding to its receptor, CD30, which is primarily found on Hodgkin lymphoma cells.

Structure

CD153 is a type II transmembrane protein that is part of the TNF superfamily. It is composed of 234 amino acids and has a molecular weight of approximately 26 kDa. The extracellular domain of CD153 is responsible for its interaction with CD30.

Function

CD153 plays a crucial role in the regulation of B cell function. It is expressed on activated T cells and binds to CD30 on B cells, leading to the activation of the B cells. This interaction is important for the proliferation and differentiation of B cells into plasma cells, which produce antibodies.

In addition to its role in B cell function, CD153 also plays a role in T cell function. It is involved in the activation and proliferation of T cells, and it can also induce apoptosis in certain T cell subsets.

Clinical significance

Abnormal expression of CD153 has been associated with several diseases, including Hodgkin lymphoma, non-Hodgkin lymphoma, and autoimmune diseases. In Hodgkin lymphoma, CD30 is highly expressed on the surface of the malignant cells, and the interaction with CD153 can contribute to the survival and proliferation of these cells.

In autoimmune diseases, overexpression of CD153 can lead to excessive activation of B cells and production of autoantibodies, contributing to the pathogenesis of these diseases.

See also

• CD30
• Tumor necrosis factor
• Hodgkin lymphoma
• Non-Hodgkin lymphoma
• Autoimmune diseases