CD30
CD30 is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. CD30 is also known as TNFRSF8 and is a cell membrane protein of the tumor necrosis factor receptor superfamily. The encoded protein is a receptor for the lymphocyte-expressed ligand CD30L. CD30 is expressed on activated, but not on resting, T cells and B cells.
Function[edit | edit source]
CD30 has a role in cell proliferation and differentiation. It is thought to have a role in lymphoma pathogenesis and may have a role in the prognosis of some types of lymphoma. CD30 is also associated with anaplastic large cell lymphoma and is a defining feature of this type of non-Hodgkin lymphoma.
Clinical significance[edit | edit source]
CD30 is used in the diagnosis of lymphomas. It is expressed in Hodgkin's lymphoma, anaplastic large cell lymphoma, and embryonal carcinoma. CD30 expression is often associated with a poorer prognosis in non-Hodgkin lymphoma.
Therapeutic use[edit | edit source]
CD30 is the target of the FDA-approved antibody-drug conjugate brentuximab vedotin (Adcetris), used in the treatment of Hodgkin lymphoma and anaplastic large cell lymphoma.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
