CXCL9
CXCL9 is a small cytokine belonging to the CXC chemokine family that is also known as Monokine induced by gamma interferon (MIG). It is secreted by activated monocytes and neutrophils and expressed in a variety of tissues. CXCL9 functions as a chemoattractant for T cells and dendritic cells by interacting with the chemokine receptor CXCR3.
Structure[edit | edit source]
CXCL9 is a 125-amino acid protein with a four-cysteine motif common to CXC chemokines. The protein structure includes a triple-stranded antiparallel beta-sheet and a C-terminal alpha-helix.
Function[edit | edit source]
CXCL9 is secreted by cells in response to IFN-gamma, and it attracts T cells and promotes T cell adhesion and migration. It is also involved in angiostasis, a process that limits the growth of new blood vessels.
Clinical significance[edit | edit source]
CXCL9 has been associated with several diseases, including autoimmune diseases, cancer, and infectious diseases. It is often upregulated in these conditions, suggesting a role in the immune response.
See also[edit | edit source]
- Chemokine
- Cytokine
- Monocyte
- Neutrophil
- T cell
- Dendritic cell
- CXCR3
- IFN-gamma
- Angiostasis
- Autoimmune diseases
- Cancer
- Infectious diseases
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Contributors: Prab R. Tumpati, MD
