XCL2
XCL2 is a chemokine protein that in humans is encoded by the XCL2 gene. It is a member of the chemokine family, a group of small (approximately 8 to 14 kDa), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors.
Function[edit | edit source]
The XCL2 gene is one of two separate genes that encode identical proteins which are associated with the chemokine XC receptor. Chemokines are a superfamily of secreted proteins involved in immunoregulation and inflammation. The XC chemokines are a subset of the chemokine family, characterized by having only two of the four conserved cysteine residues. The two XC chemokines described to date are unique among chemokines in having a three-amino acid motif (the UNY motif) immediately downstream of the CXC motif.
Clinical significance[edit | edit source]
The XCL2 gene has been implicated in various diseases, including cancer, autoimmune diseases, and infectious diseases. It is thought to play a role in the immune response and may be involved in the pathogenesis of these diseases.
See also[edit | edit source]
- Chemokine
- Leukocyte
- G protein-coupled receptor
- Immunoregulation
- Inflammation
- Cancer
- Autoimmune disease
- Infectious disease
References[edit | edit source]
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