CXCL7
CXCL7 is a small cytokine belonging to the CXC chemokine family that is also known as Neutrophil-activating peptide 2 (NAP-2). It is secreted by several cell types in response to an inflammatory stimulus. CXCL7 attracts neutrophils and affects their activation state. This chemokine can be cleaved into smaller, active peptides. Moreover, CXCL7 is also involved in wound healing and inflammation, and it has been linked to cancer.
Structure[edit | edit source]
CXCL7 is a small cytokine and a member of the CXC chemokine family. It is a protein that is made up of 101 amino acids. The protein is secreted as a pro-peptide, which can be cleaved into smaller, active peptides.
Function[edit | edit source]
CXCL7 is secreted by several cell types, including platelets, monocytes, and macrophages, in response to an inflammatory stimulus. The chemokine attracts neutrophils and affects their activation state. It is also involved in wound healing and inflammation.
Clinical significance[edit | edit source]
CXCL7 has been linked to several diseases, including cancer. It is thought to play a role in the growth and spread of cancer cells. In addition, it may also play a role in inflammatory diseases such as rheumatoid arthritis and atherosclerosis.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
