CD70

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CD70 is a protein that in humans is encoded by the CD70 gene. CD70 is a member of the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNF receptor superfamily member 27 (TNFRSF27/CD27). It is a surface antigen on activated B cells and activated T cells, and is induced by interleukin-2 (IL-2).

Function[edit | edit source]

CD70 is a transmembrane protein that is expressed on activated lymphocytes. It interacts with CD27 to play a crucial role in T cell activation, B cell proliferation and differentiation, cytotoxic T cell induction, and immunoglobulin synthesis.

Clinical significance[edit | edit source]

CD70 has been implicated in various diseases. It is overexpressed in renal cell carcinoma and is associated with poor prognosis. It is also involved in autoimmune diseases, and blocking CD70-CD27 interactions has been proposed as a therapeutic strategy.

Interactions[edit | edit source]

CD70 has been shown to interact with CD27.

References[edit | edit source]

  • et al. (1997). "CD70 is critical for CD28-independent CD8+ T cell proliferation". J. Immunol. 158 (8): 3635–3637. PMID 9103409.
  • et al. (1997). "CD70 is selectively expressed on Th1 but not on Th2 cells and is required for Th1-type immune responses". J. Immunol. 158 (9): 4026–4034. PMID 9126981.

External links[edit | edit source]

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