CD70
CD70 is a protein that in humans is encoded by the CD70 gene. CD70 is a member of the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNF receptor superfamily member 27 (TNFRSF27/CD27). It is a surface antigen on activated B cells and activated T cells, and is induced by interleukin-2 (IL-2).
Function[edit | edit source]
CD70 is a transmembrane protein that is expressed on activated lymphocytes. It interacts with CD27 to play a crucial role in T cell activation, B cell proliferation and differentiation, cytotoxic T cell induction, and immunoglobulin synthesis.
Clinical significance[edit | edit source]
CD70 has been implicated in various diseases. It is overexpressed in renal cell carcinoma and is associated with poor prognosis. It is also involved in autoimmune diseases, and blocking CD70-CD27 interactions has been proposed as a therapeutic strategy.
Interactions[edit | edit source]
CD70 has been shown to interact with CD27.
References[edit | edit source]
- et al. (1997). "CD70 is critical for CD28-independent CD8+ T cell proliferation". J. Immunol. 158 (8): 3635–3637. PMID 9103409.
- et al. (1997). "CD70 is selectively expressed on Th1 but not on Th2 cells and is required for Th1-type immune responses". J. Immunol. 158 (9): 4026–4034. PMID 9126981.
External links[edit | edit source]
- CD70 at the US National Library of Medicine Medical Subject Headings (MeSH)
CD70 Resources | |
---|---|
|
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD