CCL1

CCL1 is a small cytokine belonging to the CC chemokine family that is also known as TCA3 (T cell activation gene 3). CCL1 is expressed predominantly by T cells of the immune system, and attracts certain cells of the immune system, including monocytes, and dendritic cells. This chemokine is secreted in a glycosylated form from cells stimulated with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha.

Function

CCL1 elicits its effects on cells by binding to a cell surface chemokine receptor known as CCR8. This gene is located on chromosome 17 in humans, in a large cluster of other CC chemokines.

Clinical significance

CCL1 has been implicated in immunoregulatory and inflammatory processes. It is known to play a role in the T cell response and can influence the progression of diseases such as atherosclerosis and cancer.

See also

• Chemokine
• Cytokine
• Monocytes
• Dendritic cells
• Interleukin-1
• Tumor necrosis factor-alpha
• CCR8
• Atherosclerosis
• Cancer