Scaffold/matrix attachment region

Scaffold/Matrix Attachment Region

File:Scaffold-matrix attachment region.jpg

Illustration of a Scaffold/Matrix Attachment Region

The Scaffold/Matrix Attachment Region (S/MAR) is a crucial component of the DNA structure in eukaryotic cells. It is a primary sequence of DNA that attaches the DNA to the nuclear matrix, which is the framework of the nucleus. This attachment is essential for the organization and function of the DNA.

Function

S/MARs play a significant role in the organization and regulation of the genome. They are involved in the formation of chromatin loops, which facilitate the regulation of gene expression. S/MARs also play a role in the replication and repair of DNA, as well as in the process of cell division.

Structure

S/MARs are typically AT-rich sequences, meaning they have a high proportion of adenine and thymine bases. They are often found near the start and end of genes, where they can influence gene expression. The exact structure of S/MARs can vary between different species and cell types.

Role in Disease

Alterations in S/MARs can lead to changes in gene expression, which can contribute to the development of various diseases, including cancer. Research is ongoing to understand the role of S/MARs in disease and to develop potential therapeutic strategies.

See Also

• Chromatin
• Gene expression
• Nuclear matrix