Matrix metalloproteinase

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Matrix metalloproteinase (MMP) are a group of enzymes that, in concert with other enzymes, help to degrade the extracellular matrix. They are involved in many biological processes, including embryogenesis, normal tissue remodeling, wound healing, and disease processes such as arthritis and metastasis.

Structure[edit | edit source]

MMPs are part of the metzincin superfamily of zinc-dependent proteases. They are characterized by the presence of a highly conserved zinc-binding site in the catalytic domain, and a "Met-turn" structure that provides the correct orientation for catalysis.

Function[edit | edit source]

MMPs are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. They are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, apoptosis, and host defense.

Clinical significance[edit | edit source]

MMPs are thought to be involved in the pathogenesis of diseases such as arthritis, chronic ulcers, encephalomyelitis and cancer. They are also considered as potential therapeutic targets for the treatment of these diseases.

See also[edit | edit source]

Matrix metalloproteinase Resources
Wikipedia


References[edit | edit source]


External links[edit | edit source]

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