Mefloquine hydrochloride

Mefloquine Hydrochloride is a quinoline derivative used as an antimalarial drug. It is a synthetic compound developed by the United States Army in the 1970s. Mefloquine Hydrochloride is marketed under several brand names, including Lariam, Mefaquin, and Mefliam.

Chemistry

Mefloquine Hydrochloride is a racemic mixture, meaning it contains equal amounts of two enantiomers. It is a white to almost white crystalline compound with a melting point of 218-220°C. It is very slightly soluble in water and slightly soluble in ethanol.

Pharmacology

Mefloquine Hydrochloride acts as a blood schizonticide, a type of antimalarial drug that destroys the asexual forms of malaria parasites in the red blood cells. It is effective against the Plasmodium falciparum strain of malaria, which is resistant to chloroquine and pyrimethamine-sulfadoxine.

Usage

Mefloquine Hydrochloride is used for the prevention and treatment of malaria. It is taken orally, usually as a single dose for prevention and as a three-day course for treatment. It is not recommended for use in individuals with a history of seizures or psychiatric disorders due to the risk of neuropsychiatric side effects.

Side Effects

Common side effects of Mefloquine Hydrochloride include nausea, vomiting, diarrhea, dizziness, and sleep disturbances. Serious side effects can include seizures, hallucinations, and severe anxiety. It is recommended that individuals experiencing these side effects discontinue use and seek medical attention.

See Also

• Antimalarial medication
• Malaria
• Quinine