Megaloblast

Megaloblast

A Megaloblast is a large, abnormal, immature red blood cell (erythrocyte) found especially in the bone marrow. It is associated with Vitamin B12 or Folate deficiency, and is a characteristic feature of Megaloblastic Anemia.

Causes

Megaloblasts can be caused by a deficiency in either Vitamin B12 or Folate, both of which are necessary for DNA synthesis. This deficiency can be due to a variety of factors, including poor diet, malabsorption disorders, or the use of certain medications.

Diagnosis

Diagnosis of megaloblastic anemia involves a complete blood count (CBC) and a blood smear to identify the presence of megaloblasts. Further tests may be required to determine the underlying cause of the deficiency.

Treatment

Treatment for megaloblastic anemia involves addressing the underlying cause of the deficiency. This may involve dietary changes, supplementation with Vitamin B12 or Folate, or treatment of any underlying disorders.

See Also

• Anemia
• Pernicious Anemia
• Vitamin B12 Deficiency
• Folate Deficiency

References

Megaloblast Resources
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