Met-Enkephalin

Met-Enkephalin is a pentapeptide that functions as a neurotransmitter or neuromodulator in the nervous system. It is one of the two forms of enkephalin, the other being Leu-Enkephalin. Met-Enkephalin is derived from the proenkephalin gene and is composed of the amino acids tyrosine, glycine, glycine, phenylalanine, and methionine.

Structure and Function

Met-Enkephalin is a small peptide composed of five amino acids. It is produced and released by various types of cells in the body, including neurons in the brain and immune cells. Met-Enkephalin acts primarily on the delta opioid receptor, but also has affinity for the mu opioid receptor. It is involved in a variety of physiological processes, including pain modulation, immune response, and stress response.

Role in Pain Modulation

Met-Enkephalin plays a crucial role in the body's natural pain relief system. It binds to opioid receptors in the brain and spinal cord, inhibiting the transmission of pain signals. This mechanism is similar to that of opioid drugs like morphine, but without the risk of addiction or other serious side effects.

Role in Immune Response

Research has shown that Met-Enkephalin also plays a role in the body's immune response. It is produced by immune cells and can modulate their activity, potentially enhancing the body's ability to fight off infections and other diseases.

Potential Therapeutic Uses

Due to its role in pain modulation and immune response, Met-Enkephalin has potential therapeutic uses. It could be used as a non-addictive painkiller or as a treatment for immune disorders. However, more research is needed to fully understand its mechanisms of action and potential side effects.

File:Met-enkephalin.svg

Chemical structure of Met-Enkephalin

See Also

• Opioid peptide
• Endorphin
• Dynorphin

References

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