Meyer Gate
Meyer Gate is a term used in the field of biochemistry and molecular biology to describe a specific mechanism of enzyme regulation. This concept is named after the scientist who first proposed it, Dr. Meyer. The Meyer Gate mechanism involves the regulation of enzyme activity through conformational changes that are induced by the binding of specific molecules.
Mechanism[edit | edit source]
The Meyer Gate mechanism operates through a series of conformational changes in the enzyme structure. When a regulatory molecule binds to the enzyme, it induces a change in the enzyme's shape. This change can either activate or inhibit the enzyme's catalytic activity. The binding site for the regulatory molecule is often distinct from the enzyme's active site, a phenomenon known as allosteric regulation.
Significance[edit | edit source]
The Meyer Gate mechanism is significant because it provides a means for the cell to finely tune enzyme activity in response to changing conditions. This type of regulation is crucial for maintaining homeostasis and allows for rapid responses to environmental changes. It is particularly important in metabolic pathways where the flux of metabolites needs to be tightly controlled.
Examples[edit | edit source]
Several well-known enzymes are regulated through the Meyer Gate mechanism. One example is phosphofructokinase, a key enzyme in the glycolysis pathway. The binding of ATP to an allosteric site on phosphofructokinase induces a conformational change that reduces its activity, thereby regulating the rate of glycolysis.
Research[edit | edit source]
Ongoing research in the field of enzyme regulation continues to uncover new examples of the Meyer Gate mechanism. Advances in structural biology techniques, such as X-ray crystallography and NMR spectroscopy, have been instrumental in elucidating the detailed mechanisms by which these conformational changes occur.
Related Pages[edit | edit source]
- Enzyme
- Allosteric regulation
- Phosphofructokinase
- Glycolysis
- Homeostasis
- Structural biology
- X-ray crystallography
- NMR spectroscopy
Categories[edit | edit source]
.svg){kind=small} | This biochemistry article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
