Hexafluronium bromide

Hexafluronium bromide is a neuromuscular-blocking drug or muscle relaxant in the category of non-depolarizing curare-mimetic muscle relaxants. It is used in anesthesia to induce muscle relaxation during surgery. Hexafluronium bromide is a long-acting, non-depolarizing skeletal muscle relaxant. It was withdrawn from the market due to its potential to cause histamine release and cardiovascular side effects.

Etymology

The term "Hexafluronium bromide" is derived from its chemical structure. The prefix "hexa-" refers to the six fluorine atoms in the molecule, "-onium" is a common ending for quaternary ammonium cations, and "bromide" refers to the bromine atom in the molecule.

Pharmacology

Hexafluronium bromide acts by blocking the action of acetylcholine at the neuromuscular junction, thereby inhibiting the transmission of nerve impulses to the muscles. This results in muscle relaxation and paralysis, which is useful in surgical procedures where muscle movement could interfere with the operation.

Side Effects

The most common side effects of Hexafluronium bromide include hypotension (low blood pressure), bradycardia (slow heart rate), and bronchospasm (constriction of the airways). These side effects are generally manageable with appropriate medical intervention.

Related Terms

• Neuromuscular-blocking drug
• Muscle relaxant
• Curare
• Anesthesia
• Acetylcholine
• Neuromuscular junction
• Hypotension
• Bradycardia
• Bronchospasm

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