Mitochondrial genome
Mitochondrial Genome
The mitochondrial genome refers to the genetic material within mitochondria, the organelles that generate energy for the cell. Mitochondrial DNA is not transmitted through nuclear DNA. In humans, the mitochondrial genome contains 37 genes, all of which are essential for normal mitochondrial function.
Structure[edit | edit source]
The mitochondrial genome is a circular DNA molecule, similar to the DNA of bacteria. This circular structure is a key feature that distinguishes it from the linear DNA found in the nucleus. The mitochondrial genome is compact, with few non-coding regions and no introns.
Genes[edit | edit source]
The human mitochondrial genome encodes 13 proteins, 22 tRNAs, and 2 rRNAs. The proteins are all subunits of enzyme complexes of the oxidative phosphorylation system, which generates ATP, the cell's main source of energy. The tRNAs and rRNAs are necessary for protein synthesis within the mitochondria.
Inheritance[edit | edit source]
Mitochondrial DNA is inherited solely from the mother, a pattern known as maternal inheritance. This is because the mitochondria in mammalian sperm are usually destroyed by the egg cell after fertilization. In contrast, the egg cell's mitochondria, and therefore the mitochondrial DNA, remain intact.
Mutations and Disease[edit | edit source]
Mutations in the mitochondrial genome can lead to a range of diseases, collectively known as mitochondrial diseases. These are often debilitating and sometimes fatal conditions that can affect almost any part of the body. Examples include Leber's hereditary optic neuropathy and mitochondrial myopathy.
Research and Medicine[edit | edit source]
The mitochondrial genome is a focus of research in many fields, including genetics, biochemistry, and medicine. Understanding the mitochondrial genome and its functions can lead to treatments for mitochondrial diseases and insights into aging and other processes.
See Also[edit | edit source]
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