Mu-opioid receptor

Mu-opioid receptor (MOR) is a type of opioid receptor with high affinity for enkephalins and beta-endorphin but low affinity for dynorphins. It is also the primary receptor target for morphine, a potent opioid analgesic. The mu-opioid receptor is a member of the opioid family of G-protein coupled receptors, and its proper function is critical for pain and analgesia.

Structure

The mu-opioid receptor is a G protein-coupled receptor (GPCR) that responds to the opiate class of drugs. It is encoded by the OPRM1 gene. The receptor is a 400 amino acid polypeptide, with a molecular weight of approximately 50kDa.

Function

When an opioid binds to the mu-opioid receptor, it prevents the release of inhibitory neurotransmitters by the cell, leading to an overall increase in the firing rate of the neuron. This results in an increase in the release of certain neurotransmitters, including dopamine, which leads to a feeling of euphoria.

Clinical significance

The mu-opioid receptor is the primary target of most opioid drugs, including both natural opiates like morphine and synthetic opioids like fentanyl. These drugs are used clinically for their analgesic, antidiarrheal, and antitussive effects.

See also

• Opioid receptor
• Delta opioid receptor
• Kappa opioid receptor
• Opioid

References

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