Norflurane

From WikiMD's Wellness Encyclopedia


Norflurane, also known by its chemical formula C2H2F4 and commonly referred to as R-134a, is a hydrofluorocarbon (HFC) used primarily as a high-temperature refrigerant for domestic refrigeration and automobile air conditioners. Norflurane is also used as a propellant in pharmaceutical delivery systems and as a blowing agent in foam plastics.

Properties[edit | edit source]

Norflurane is a colorless, non-flammable gas under ambient conditions and has a slightly ether-like odor. It is chemically stable but can decompose under high temperature to form hazardous products such as hydrofluoric acid.

Applications[edit | edit source]

      1. Refrigeration

Norflurane is widely used in the refrigeration industry due to its low toxicity and relatively good efficiency. It has been adopted as a replacement for chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs) which are known to cause ozone depletion.

      1. Medical Use

In the medical field, Norflurane is utilized as a propellant in metered-dose inhalers (MDIs) for medications used in treating asthma and other respiratory conditions.

      1. Foam Blowing

Norflurane serves as a blowing agent in the production of foam plastics, contributing to the material's insulation properties.

Environmental Impact[edit | edit source]

Although Norflurane does not deplete the ozone layer, it is a potent greenhouse gas with a high global warming potential (GWP). Efforts are ongoing to find more environmentally friendly alternatives with lower GWP.

Safety[edit | edit source]

Norflurane is generally safe for use in various applications but should be handled with care to avoid inhalation in high concentrations, which can lead to asphyxiation.

Regulation[edit | edit source]

Due to its environmental impact, the use of Norflurane is regulated under various international agreements and standards aimed at reducing emissions and eventually phasing out substances with high global warming potential.

Contributors: Prab R. Tumpati, MD