Nitroxoline
(Redirected from Noxibiol)
An article about the antibiotic Nitroxoline
Nitroxoline is an antibiotic used primarily in the treatment of urinary tract infections (UTIs). It is a synthetic compound belonging to the class of 8-hydroxyquinoline derivatives. Nitroxoline is known for its broad-spectrum antimicrobial activity, particularly against Gram-positive and Gram-negative bacteria.
Mechanism of Action[edit | edit source]
Nitroxoline exerts its antibacterial effects by chelating metal ions that are essential for bacterial growth and metabolism. This chelation disrupts the function of bacterial enzymes, leading to inhibition of DNA synthesis and ultimately bacterial cell death. The drug is particularly effective against Escherichia coli, a common causative agent of UTIs.
Pharmacokinetics[edit | edit source]
After oral administration, nitroxoline is rapidly absorbed from the gastrointestinal tract. It is metabolized in the liver and excreted primarily in the urine, where it achieves high concentrations, making it particularly effective for treating urinary tract infections. The drug's half-life allows for dosing multiple times a day to maintain therapeutic levels.
Clinical Uses[edit | edit source]
Nitroxoline is primarily indicated for the treatment of uncomplicated urinary tract infections. It is also used in some cases for prophylaxis in patients undergoing urological procedures. Its use is limited in some regions due to the availability of newer antibiotics with broader spectra of activity.
Side Effects[edit | edit source]
Common side effects of nitroxoline include gastrointestinal disturbances such as nausea and vomiting. Some patients may experience allergic reactions, including skin rashes. Rarely, nitroxoline can cause peripheral neuropathy or optic neuritis, particularly with prolonged use.
Contraindications[edit | edit source]
Nitroxoline is contraindicated in patients with known hypersensitivity to 8-hydroxyquinolines. It should be used with caution in patients with severe liver or kidney impairment, as these conditions can affect the drug's metabolism and excretion.
Related pages[edit | edit source]
Nitroxoline
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
