Oxidized

Oxidized LDL

Oxidized LDL (low-density lipoprotein) is a form of lipoprotein that has been modified by oxidation. It plays a crucial role in the development of atherosclerosis, a disease in which plaque builds up inside your arteries.

Overview

LDL is often referred to as "bad cholesterol" because high levels of LDL can lead to an increase in the risk of heart disease. When LDL is oxidized, it becomes more harmful and can contribute to the development of atherosclerosis.

Role in Atherosclerosis

Oxidized LDL contributes to atherosclerosis in several ways. It can cause damage to the endothelium, the inner lining of the arteries. This damage can lead to the formation of plaque, a hard substance that can narrow or block the arteries. Oxidized LDL can also stimulate the production of inflammatory molecules, which can further contribute to the development of atherosclerosis.

Detection and Measurement

The level of oxidized LDL in the blood can be measured using a variety of methods. These include ELISA (enzyme-linked immunosorbent assay), a common laboratory technique used to detect and measure substances such as proteins and antibodies in samples.

Prevention and Treatment

Lifestyle changes, such as eating a healthy diet and getting regular exercise, can help to lower levels of LDL and reduce the risk of atherosclerosis. Medications, such as statins, can also be used to lower LDL levels.

See Also

• Cholesterol
• Heart disease
• Atherosclerosis
• Statins

References

Oxidized Resources
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