SCN9A
SCN9A is a gene that in humans is responsible for encoding the alpha subunit of the voltage-gated sodium channel Nav1.7. This channel is found in peripheral neurons and plays a crucial role in the generation and conduction of action potentials, which are changes in electrical properties that are the basis for cell-to-cell communication in the nervous system.
Function[edit | edit source]
SCN9A encodes a voltage-gated sodium channel which is a crucial component of the nervous system. It is responsible for the initiation and propagation of action potentials in neurons. Mutations in this gene have been associated with primary erythermalgia, paroxysmal extreme pain disorder, and congenital insensitivity to pain.
Clinical significance[edit | edit source]
Mutations in the SCN9A gene are associated with a number of pain-related conditions. These include primary erythromelalgia, paroxysmal extreme pain disorder, and congenital insensitivity to pain. In addition, research has suggested a potential role for SCN9A in other conditions such as chronic pain and epilepsy.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
| SCN9A Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
