SCN9A

SCN9A is a gene that in humans is responsible for encoding the alpha subunit of the voltage-gated sodium channel Nav1.7. This channel is found in peripheral neurons and plays a crucial role in the generation and conduction of action potentials, which are changes in electrical properties that are the basis for cell-to-cell communication in the nervous system.

Function

SCN9A encodes a voltage-gated sodium channel which is a crucial component of the nervous system. It is responsible for the initiation and propagation of action potentials in neurons. Mutations in this gene have been associated with primary erythermalgia, paroxysmal extreme pain disorder, and congenital insensitivity to pain.

Clinical significance

Mutations in the SCN9A gene are associated with a number of pain-related conditions. These include primary erythromelalgia, paroxysmal extreme pain disorder, and congenital insensitivity to pain. In addition, research has suggested a potential role for SCN9A in other conditions such as chronic pain and epilepsy.

See also

• Sodium channel
• Voltage-gated ion channel
• Pain

External links

• SCN9A at NCBI
• SCN9A at GHR

SCN9A Resources
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