SKF-77434

SKF-77434 is a pharmacological compound that is often used in scientific research. It is a potent and selective dopamine D1 receptor antagonist, which means it blocks the action of dopamine at the D1 receptor. This makes it a valuable tool in the study of dopamine's role in the brain and body.

Pharmacology

SKF-77434 is a dopamine antagonist, specifically a D1 antagonist. Dopamine is a type of neurotransmitter, a chemical that transmits signals in the brain. There are several types of dopamine receptors in the brain, and SKF-77434 specifically blocks the D1 type. This means that it prevents dopamine from binding to these receptors and activating them.

Uses in Research

Due to its specific action on D1 receptors, SKF-77434 is often used in research to study the role of these receptors in various physiological and pathological processes. For example, it has been used in studies investigating the role of D1 receptors in Parkinson's disease, schizophrenia, and drug addiction.

Chemistry

The chemical structure of SKF-77434 is characterized by a phenyl ring attached to a piperidine ring, which is a common structure in many pharmacologically active compounds. The specific arrangement of atoms and functional groups in SKF-77434 gives it its unique pharmacological properties.

Safety and Toxicity

As with any pharmacological compound, SKF-77434 has the potential to cause adverse effects if not used properly. However, it is generally considered safe for use in laboratory research when handled by trained professionals. The specific safety and toxicity profile of SKF-77434 is not well-studied, and it is not intended for use in humans or animals outside of a research setting.

See Also

• Dopamine
• Dopamine antagonist
• Dopamine D1 receptor
• Neurotransmitter
• Pharmacology

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