SKF-81297

SKF-81297 is a synthetic compound that is often used in scientific research. It is a selective D1-like receptor agonist, meaning it stimulates the activity of these receptors in the brain. SKF-81297 has been used in various studies to investigate the role of D1-like receptors in behavior and disease.

Chemistry[edit | edit source]

SKF-81297 belongs to the class of phenethylamine derivatives. It is a synthetic compound, meaning it is not found naturally but is produced in a laboratory. The chemical structure of SKF-81297 includes a benzazepine ring, which is a seven-membered ring with one nitrogen atom.

Pharmacology[edit | edit source]

SKF-81297 is a selective agonist for D1-like receptors, which include D1 and D5 receptors. An agonist is a substance that binds to a receptor and activates it, thereby producing a biological response. In the case of SKF-81297, this response is an increase in the activity of D1-like receptors.

D1-like receptors are one of the two main classes of dopamine receptors in the brain, the other being D2-like receptors. They are involved in a variety of functions, including motor control, cognition, and reward. By selectively activating D1-like receptors, SKF-81297 can be used to study these functions in detail.

Research Uses[edit | edit source]

SKF-81297 has been used in a variety of research contexts. For example, it has been used to study the role of D1-like receptors in Parkinson's disease, a neurodegenerative disorder characterized by the loss of dopamine-producing neurons. By activating D1-like receptors, SKF-81297 can help to compensate for this loss and alleviate the symptoms of the disease.

In addition, SKF-81297 has been used to investigate the role of D1-like receptors in drug addiction. Some studies have suggested that these receptors may be involved in the rewarding effects of drugs of abuse, and that activating them with SKF-81297 can reduce drug-seeking behavior.