Somatomedin

Somatomedin refers to a group of proteins that are produced in the liver when stimulated by growth hormone (GH). They are also known as Insulin-like growth factors (IGFs) due to their structural similarity to insulin. The two most well-known types of somatomedin are Somatomedin C (also known as IGF-1) and Somatomedin A (also known as IGF-2).

Function

Somatomedins have a variety of functions in the body. They are primarily involved in promoting growth and development, particularly during childhood and adolescence. They do this by stimulating the growth of bone and muscle, and by promoting cell division and differentiation. In addition to their role in growth, somatomedins also have metabolic effects. They can increase glucose uptake and utilization, and they can promote protein synthesis.

Clinical significance

Abnormal levels of somatomedin can lead to a variety of health problems. High levels can lead to acromegaly, a condition characterized by excessive growth of the hands, feet, and face. Low levels can lead to growth hormone deficiency, which can result in short stature and delayed growth. Somatomedin levels can also be affected by malnutrition, liver disease, and certain genetic disorders.

Measurement

Somatomedin levels can be measured in the blood using a variety of techniques. These include radioimmunoassay, enzyme-linked immunosorbent assay (ELISA), and mass spectrometry. These tests can be used to diagnose conditions related to growth hormone and to monitor the effectiveness of treatment.

See also

• Growth hormone
• Insulin-like growth factor
• Acromegaly
• Growth hormone deficiency

Somatomedin Resources
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