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Odalasvir
...or]], a type of drug that interferes with the replication of the Hepatitis C virus. ...such as [[Sofosbuvir]] and [[Velpatasvir]], for the treatment of Hepatitis C.

1 KB (213 words) - 03:43, 2 March 2024
Uprifosbuvir
...in, which is a key component of the viral replication process in Hepatitis C. ...nt RNA polymerase]] that is essential for the replication of the Hepatitis C virus. By blocking this protein, Uprifosbuvir prevents the virus from repli

1 KB (195 words) - 19:27, 29 February 2024
Protease inhibitors
...and blocking proteolytic cleavage of protein precursors that are necessary for the production of infectious viral particles. ...roteases, enzymes that cleave proteins. Viruses, such as HIV and hepatitis C, rely on proteases to cleave large protein molecules into smaller proteins.

2 KB (277 words) - 16:31, 4 March 2024
Samatasvir
...erimental drug that was under development for the treatment of [[Hepatitis C]]. It is a direct-acting antiviral agent (DAA) and was being developed by [ ...were being developed to improve upon the existing treatments for Hepatitis C, which often had severe side effects and were not always effective.

1 KB (211 words) - 15:35, 2 March 2024
NS3 (HCV)
...ral replication]] process of the Hepatitis C virus, making it a key target for [[antiviral]] drug development. ...n and a C-terminal [[helicase]] domain. The protease domain is responsible for cleaving the [[polyprotein]] precursor into individual viral proteins, whil

2 KB (237 words) - 12:18, 10 March 2024
Protease Inhibitors
...and blocking proteolytic cleavage of protein precursors that are necessary for the production of infectious viral particles. ...ease inhibitors are almost always used in combination with other antiviral drugs to increase their effectiveness and prevent the development of drug resista

2 KB (240 words) - 16:14, 2 March 2024
Ledipasvir and sofosbuvir
...in the treatment of [[hepatitis C]]. It is a combination of two antiviral drugs, [[ledipasvir]] and [[sofosbuvir]]. The medication is taken orally, and it ...nalogue]] that inhibits the [[NS5B polymerase]], another protein necessary for the virus to reproduce.

1 KB (207 words) - 00:15, 6 March 2024
Setrobuvir
...nt of [[Hepatitis C]]. It is a non-nucleoside inhibitor of the [[Hepatitis C virus]] (HCV) [[RNA-dependent RNA polymerase]], an essential component of t ...on is different from that of other antiviral drugs used to treat Hepatitis C, which typically target the viral protease or NS5A protein.

2 KB (258 words) - 14:12, 2 March 2024
Hepacivirus
...this genus is the [[Hepatitis C virus]] (HCV), which is a major cause of [[hepatitis]] worldwide. Other species in this genus are known to infect horses, rodent ...er species include ''Hepacivirus A'', ''Hepacivirus B'', and ''Hepacivirus C'', among others.

2 KB (234 words) - 20:26, 5 March 2024
Radalbuvir
...epatitis C]]. It is a [[nucleotide analogue]] inhibitor of the [[Hepatitis C virus]] NS5B polymerase. ...drug is currently in the experimental stage and has not yet been approved for use in humans.

2 KB (221 words) - 22:38, 23 February 2024
Sofosbuvir/velpatasvir/voxilaprevir
...s a fixed-dose combination medication used in the treatment of [[hepatitis C]]. It contains three active ingredients: [[sofosbuvir]], [[velpatasvir]], a ...atasvir, and voxilaprevir. Sofosbuvir is a nucleotide analogue [[hepatitis C virus]] (HCV) NS5B polymerase inhibitor, velpatasvir is an HCV NS5A inhibit

2 KB (235 words) - 20:13, 29 February 2024
Discovery And Development Of NS5A Inhibitors
...ural protein that plays a crucial role in the replication of the Hepatitis C virus. ...for the replication of the Hepatitis C virus, making it a promising target for antiviral therapy. Early attempts to develop NS5A inhibitors were hampered

2 KB (329 words) - 18:54, 11 March 2024
Miravirsen
...nucleotide]] that binds to [[microRNA-122]], a molecule that the hepatitis C virus uses to replicate. By binding to microRNA-122, miravirsen prevents th ...122, a small RNA molecule that is highly expressed in the liver. Hepatitis C virus (HCV) uses microRNA-122 to replicate. By binding to microRNA-122, mir

2 KB (227 words) - 03:57, 6 March 2024
Mericitabine
...ne]] analogue, and it works by inhibiting the replication of the hepatitis C virus. ...ricitabine due to the emergence of more effective treatments for hepatitis C.

1 KB (194 words) - 02:39, 29 February 2024
Narlaprevir
...hibitor]], specifically targeting the [[NS3/4A]] protease of the Hepatitis C virus. ...ially tested in [[clinical trials]] as a potential treatment for Hepatitis C, but development was discontinued in 2013.

2 KB (250 words) - 21:53, 25 February 2024
Olgotrelvir
...iviral drug]] currently under development for the treatment of [[Hepatitis C]]. It is a [[prodrug]] of [[VX-222]], a non-nucleoside NS5B polymerase inhi ...NS5B polymerase, an enzyme essential for the replication of the Hepatitis C virus.

2 KB (262 words) - 00:13, 6 March 2024
Ledipasvir/Sofosbuvir
...for the treatment of [[hepatitis C]]. It is a combination of two antiviral drugs, [[ledipasvir]] and [[sofosbuvir]]. This combination therapy is marketed un ...nalogue]] that inhibits the [[NS5B polymerase]], another protein necessary for the virus to reproduce.

2 KB (256 words) - 05:44, 11 March 2024
GS-6620
...[[Gilead Sciences]] for the treatment of [[hepatitis C virus]] (HCV) and [[hepatitis B virus]] (HBV) infections. It is a nucleotide analogue inhibitor of the vi ...merase]] enzyme of the hepatitis C and B viruses. This enzyme is essential for the replication of the virus. By inhibiting this enzyme, GS-6620 prevents t

1 KB (209 words) - 00:30, 11 March 2024
Gilead Sciences
...viral drugs used in the treatment of [[HIV]], [[hepatitis B]], [[hepatitis C]], and [[influenza]], including [[Harvoni]] and [[Sovaldi]]. ...ny name "Gilead" refers to the [[Balm of Gilead]], a historic region known for its medicinal plants.

2 KB (261 words) - 21:00, 10 March 2024
Ravidasvir
...itis C virus. Ravidasvir is often used in combination with other antiviral drugs to increase the effectiveness of treatment. ...osphoprotein that plays a crucial role in the replication of the Hepatitis C virus. By binding to this protein, Ravidasvir prevents the virus from repli

2 KB (247 words) - 14:40, 2 March 2024