Miravirsen
Miravirsen is an experimental drug for the treatment of hepatitis C. It is an antisense oligonucleotide that binds to microRNA-122, a molecule that the hepatitis C virus uses to replicate. By binding to microRNA-122, miravirsen prevents the virus from replicating, thereby reducing the amount of virus in the body.
Mechanism of action[edit | edit source]
Miravirsen is a locked nucleic acid (LNA) antisense oligonucleotide. It works by binding to microRNA-122, a small RNA molecule that is highly expressed in the liver. Hepatitis C virus (HCV) uses microRNA-122 to replicate. By binding to microRNA-122, miravirsen prevents HCV from using this molecule, thereby inhibiting viral replication.
Clinical trials[edit | edit source]
Miravirsen has been tested in phase 2 clinical trials. In a study published in 2013, patients with chronic hepatitis C who were treated with miravirsen had a significant reduction in viral load. The drug was well tolerated, with no serious adverse events reported.
Potential advantages[edit | edit source]
Miravirsen has several potential advantages over other treatments for hepatitis C. Because it targets a human molecule (microRNA-122) rather than a viral protein, the virus may be less likely to develop resistance to miravirsen. In addition, because microRNA-122 is highly expressed in the liver, miravirsen may have fewer side effects than drugs that target viral proteins.
See also[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
