Miravirsen
Miravirsen is an experimental drug for the treatment of hepatitis C. It is an antisense oligonucleotide that binds to microRNA-122, a molecule that the hepatitis C virus uses to replicate. By binding to microRNA-122, miravirsen prevents the virus from replicating, thereby reducing the amount of virus in the body.
Mechanism of action[edit | edit source]
Miravirsen is a locked nucleic acid (LNA) antisense oligonucleotide. It works by binding to microRNA-122, a small RNA molecule that is highly expressed in the liver. Hepatitis C virus (HCV) uses microRNA-122 to replicate. By binding to microRNA-122, miravirsen prevents HCV from using this molecule, thereby inhibiting viral replication.
Clinical trials[edit | edit source]
Miravirsen has been tested in phase 2 clinical trials. In a study published in 2013, patients with chronic hepatitis C who were treated with miravirsen had a significant reduction in viral load. The drug was well tolerated, with no serious adverse events reported.
Potential advantages[edit | edit source]
Miravirsen has several potential advantages over other treatments for hepatitis C. Because it targets a human molecule (microRNA-122) rather than a viral protein, the virus may be less likely to develop resistance to miravirsen. In addition, because microRNA-122 is highly expressed in the liver, miravirsen may have fewer side effects than drugs that target viral proteins.
See also[edit | edit source]
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