Uprifosbuvir

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Uprifosbuvir is an experimental antiviral drug currently under development for the treatment of Hepatitis C. It is a nucleotide analogue inhibitor, specifically targeting the NS5B protein, which is a key component of the viral replication process in Hepatitis C.

Mechanism of Action[edit | edit source]

Uprifosbuvir works by inhibiting the NS5B protein, a RNA-dependent RNA polymerase that is essential for the replication of the Hepatitis C virus. By blocking this protein, Uprifosbuvir prevents the virus from replicating and spreading within the body.

Development and Clinical Trials[edit | edit source]

The development of Uprifosbuvir is being led by Gilead Sciences, a biopharmaceutical company based in the United States. The drug is currently in Phase 2 clinical trials, where it is being tested for its safety, efficacy, and optimal dosage in patients with Hepatitis C.

Potential Impact[edit | edit source]

If approved, Uprifosbuvir could provide a new treatment option for patients with Hepatitis C, particularly those who have not responded to existing treatments. However, as with all experimental drugs, the safety and efficacy of Uprifosbuvir will need to be confirmed through further clinical trials.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD