Ledipasvir/Sofosbuvir
| Ledipasvir/Sofosbuvir | |
|---|---|
| [[File:|frameless|220px|alt=|]] | |
| INN | |
| Drug class | |
| Routes of administration | Oral |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | |
| PubChem | 67505836 |
| DrugBank | DB09027 |
| ChemSpider | 29766870 |
| KEGG | D10567 |
Ledipasvir/sofosbuvir, sold under the brand name Harvoni, is a fixed-dose combination medication used to treat hepatitis C. It is a combination of ledipasvir and sofosbuvir.
Medical uses[edit | edit source]
Ledipasvir/sofosbuvir is used to treat chronic hepatitis C genotype 1, 4, 5, or 6 infection in adults and children aged 3 years and older. It is also used in combination with ribavirin to treat hepatitis C virus (HCV) in patients with decompensated cirrhosis.
Mechanism of action[edit | edit source]
Ledipasvir is an NS5A inhibitor, which interferes with the HCV viral replication process. Sofosbuvir is a nucleotide analog NS5B polymerase inhibitor, which inhibits the RNA polymerase enzyme necessary for viral replication. Together, they prevent the virus from multiplying and infecting new cells.
Side effects[edit | edit source]
Common side effects of ledipasvir/sofosbuvir include fatigue, headache, and nausea. Serious side effects may include bradycardia when taken with amiodarone.
Interactions[edit | edit source]
Ledipasvir/sofosbuvir may interact with other medications, including antacids, proton pump inhibitors, and HIV medications. It is important to consult with a healthcare provider before starting any new medications.
History[edit | edit source]
Ledipasvir/sofosbuvir was approved for medical use in the United States in 2014. It was the first combination pill approved to treat hepatitis C without the need for interferon or ribavirin.
References[edit | edit source]
External links[edit | edit source]
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