NS5B

NS5B is a RNA-dependent RNA polymerase that is encoded by the NS5B gene. It is a vital component of the Hepatitis C virus (HCV) replication complex and plays a crucial role in the replication of the HCV genome.

Structure

NS5B is a 65-kDa protein that consists of 591 amino acids. It has a unique structure that resembles a right hand, with fingers, palm, and thumb subdomains. The active site of the enzyme is located in the palm subdomain, while the fingers and thumb subdomains are involved in the binding of RNA.

Function

The primary function of NS5B is to catalyze the synthesis of new RNA strands from the HCV RNA template. This process is known as RNA replication. NS5B has a high error rate, which contributes to the high genetic variability of HCV.

Role in Disease

Due to its essential role in HCV replication, NS5B is a major target for antiviral drugs. Inhibitors of NS5B, known as NS5B inhibitors, are used in the treatment of Hepatitis C.

See Also

• Hepatitis C virus
• RNA-dependent RNA polymerase
• NS5B inhibitors

References

Template:Viral proteins Template:Hepatitis C

NS5B Resources
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