Zanamivir

Zanamivir is a substance that is being studied in the treatment of prostate cancer.

Zanamivir structure

Class[edit | edit source]

It belongs to the family of drugs called endothelin-receptor antagonists.

Zanamivir is an inhibitor of the influenza neuramidase enzyme and is given by inhalation as therapy and prophylaxis against influenza A and B.
Zanamivir may be used to treat and prevent infections from influenza A (H1N1).

Zanamivir has not been associated with clinically apparent liver injury, at least when given by inhalation.

Zanamivir (za nam' i vir) is a sialic acid analogue and a potent inhibitor of the neuraminidase of influenza viruses.
Inhibition of this enzyme causes a decrease in viral replication, probably as a result of interference with particle formation and release. Zanamivir is active against both influenza A and B viruses, but has no activity against other common upper respiratory tract viruses.
In addition, resistance to zanamivir can develop rapidly.
Zanamivir is indicated for therapy or post-exposure prevention of influenza A or B.

Zanamivir was approved in the United States in 1999 and is frequently used during influenza outbreaks.
Zanamivir is available as a powder for inhalation (5 mg/blister pack) under the brand name of Relenza.

The recommended dose for therapy in adults is 2 oral inhalations of 5 mg each, twice daily for 5 days;
the usual prophylactic regimen is 10 mg once daily for 10 days, starting within 2 days of close contact with an infected person or for 28 days in a community setting.

Side effects are uncommon and include mild nausea, dizziness, headache, cough, nasal and throat irritation and bronchospasm.

difficulty breathing
wheezing
shortness of breath
hives
rash
itching
difficulty swallowing
swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
hoarseness

Relenza®

The lowest GoodRx price for the most common version of Relenza is around $69.40, 9% off the average retail price of $76.28.

Zanamivir Resources
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