Rifabutin

Antibiotic used to treat tuberculosis and Mycobacterium avium complex

Rifabutin
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Rifabutin is an antibiotic that is primarily used to treat tuberculosis and infections caused by the Mycobacterium avium complex (MAC). It is a member of the rifamycin class of antibiotics, which are known for their ability to inhibit bacterial RNA polymerase.

Medical uses

Rifabutin is used in the treatment and prevention of Mycobacterium avium complex infections, particularly in patients with HIV/AIDS. It is also used as part of combination therapy for tuberculosis, especially in cases where rifampicin cannot be used due to drug interactions or resistance.

Mycobacterium avium complex

Chemical structure of Rifabutin

Rifabutin is effective against the Mycobacterium avium complex, which includes several species of mycobacteria that can cause serious infections in immunocompromised individuals. It is often used in combination with other antibiotics such as clarithromycin or azithromycin to prevent or treat these infections.

Tuberculosis

Rifabutin is used as an alternative to rifampicin in the treatment of tuberculosis, particularly in patients who are receiving antiretroviral therapy for HIV/AIDS. This is because rifabutin has fewer drug interactions compared to rifampicin, making it a preferred choice in these cases.

Mechanism of action

Rifabutin works by inhibiting the bacterial DNA-dependent RNA polymerase, an enzyme that is crucial for the transcription of DNA into RNA. By blocking this enzyme, rifabutin effectively halts the synthesis of bacterial RNA, leading to the death of the bacteria.

Side effects

Common side effects of rifabutin include gastrointestinal disturbances such as nausea and vomiting, as well as skin rashes. More serious side effects can include neutropenia, uveitis, and hepatitis. Patients taking rifabutin may also experience a reddish-orange discoloration of bodily fluids, which is harmless but can be alarming.

Drug interactions

Rifabutin is known to interact with several other medications, particularly those that are metabolized by the cytochrome P450 enzyme system. It can induce the metabolism of drugs such as protease inhibitors and non-nucleoside reverse transcriptase inhibitors, which are used in the treatment of HIV/AIDS.

Related pages

• Rifampicin
• Antibiotic
• Tuberculosis
• Mycobacterium avium complex